Understanding autism through Metabolomics
A simple, at-home test to guide more informed choices
Autism it is a pervasive and pervasive developmental disorder, which involves impairment of social interaction, communication, and communication comprehension. The severity and onset of symptoms varies greatly, and this is precisely what make it difficult to structure suitable interventions.
It is believed today that the cause of autism is multifactorial. The genetic component is undeniable, but it is not a specific gene, but rather a familial predisposition, which various epigenetic mechanisms, induced by environmental factors, can unleash if they intervene at a particularly important and potentially vulnerable time in neurodevelopment, such as during pregnancy, at birth, or in the postnatal period.
The decisive role of the intestinal microbiota
Recent data shows that aalteration of the intestinal microbiota (set of bacteria and microorganisms present in the intestine, and their functional products) is instrumental in the development of autism symptoms. The functionality of the central nervous system and the gastrointestinal system is closely connected through a two-way neurohormonal communication system known as the “gut-brain axis”. The microbiome influences the central nervous system in both normal and pathological conditions, modulating gene expression through epigenetic mechanisms and influencing immune and metabolic functions, with the production of specific metabolites. For this reason, the use of metabolomics It is a useful and targeted approach to identify the metabolic signature characteristic of the pathology.
What can metabolomics reveal?
There metabolomics It is one of the most innovative scientific disciplines and aims to identify the metabolites involved in metabolic processes of cells, tissues, and organs. Their composition constantly varies based on physiological state and interactions with the environment, activating new metabolic pathways. Significant changes in the pathways involving phenylalanine, tyrosine, 4-hydroxyphenylacetic acid, hippuric acid, and tryptophan. Metabolomic analysis can therefore contribute to a diagnosis earlier and more accurate.
The intestinal microbiota is altered, with an increase in “active” bacteria (e.g. Clostridium difficile, Candida albicans) and a reduction in “good” bacteria (the so-called “old friends of man”, such as Lactobacilli and Bifidobacteria). This dysbiosis cause:
- intestinal hyperpermeability (leaky gut), which favors the neuroinflammation;
- production of toxic metabolites as P-cresol, excess propionic acid, phenols and indole derivatives.
Among the most critical metabolites there are also p-hydroxyphenylacetic acid, 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid and hippuric acid, That alter mitochondrial function. Propionic acid, although useful in normal quantities, if present in excess interferes with the Krebs cycle, hindering energy production and associating with neurological disorders. Mitochondrial alterations promote chronic neuroinflammation, characterized by an increase in interleukin-6, TNF-α, interferon-γ and other neurotransmitters.
Mitochondrial abnormalities are documented in children with autism spectrum disorders: reduced number of mitochondria, reduced functionality, altered morphology, poor repair capacity and reduced energy production. Finally, there were also alterations in intracellular calcium and one imbalance between apoptosis and autophagy, which contribute to cell damage.
Understand the secrets of your body
in three simple steps:
Preparation:
Register and, after contacting the courier to arrange collection using the number provided, follow the instructions for urine collection, ensuring the integrity of the sample in the sterile container.
Transport:
Follow packaging instructions to ensure the safety of the sample during transport. Proper shipping is essential for accurate results.
Outcome:
After shipping, you can confidently await the results. We recommend sharing the results with a specialist for a thorough analysis and personalized treatment plan.
Understand the secrets of your body
in three simple steps:
Preparation:
Register and, after contacting the courier to arrange collection using the number provided, follow the instructions for urine collection, ensuring the integrity of the sample in the sterile container.
Transport:
Follow packaging instructions to ensure the safety of the sample during transport. Proper shipping is essential for accurate results.
Outcome:
After shipping, you can confidently await the results. We recommend sharing the results with a specialist for a thorough analysis and personalized treatment plan.
What do you get with the Home Test
Detailed analytical report: You will receive a clear report outlining the results of your metabolomic analyses, along with an interpretation of the implications for your health.
Supplementation Recommendations: We’ll include specific recommendations for supplements that can support your metabolic health, ensuring a comprehensive and personalized approach.
Personalized diet plan: We will provide you with a customized nutrition plan based on your results, designed to optimize your metabolism and improve your well-being.